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Major Research Areas
Molecule anatomy :
Structure and function of prion, £]-amyloid peptide, £\-synuclein, and apoE4 molecules in the amyloidogenesis or mechanism in prion diseases, Alzheimer's disease, Parkinsonism, and diabetic neuropathy and motoneuron diseases; in silico, in vitro, in vivo, and clinical trial studies of efficacy of novel or new potential drugs in preventing neuron death via control of signal transduction, or in differentiating cancer cells via control of signal transduction.
Contact Person
Dr R. Chau
Tel: 2819 9101
Email: chaurmw@hkucc.hku.hk
Cancer :
Cancer cell biology, intracellular signaling of oncogenes and tumour suppressor genes, cell cycle and mitotic checkpoint regulation, telomerase and cell immortalization, telomere dynamics and chromosome instability, tumour progression and metastasis, molecular basis of chemoresistance of cancer cells, hormonal carcinogenesis, epithelial and stromal interactions in carcinogenesis, molecular genetics of nasopharyngeal carcinoma and esophageal carcinoma; mechanisms of prostatic and breast carcinogenesis, molecular mechanisms involved in transformation of androgen dependent to androgen independent prostate cancer.
Contact Persons
Dr A. Cheung
Tel: 2819 9293
Email: lmcheung@hkucc.hku.hk
Professor G.S.W. Tsao
Tel: 2819 9227
Email: gswtsao@hkucc.hku.hk
Professor Y.C. Wong
Tel: 2819 9226
Email: ycwong@hkucc.hku.hk
Functional genomics:
The main research interest is to manipulate mouse genome to understand the pathogenesis of human diseases by employing the state-of-art technology, i.e., conventional and conditional transgenic/knockout mouse technology. These genetically manipulated mouse models are powerful reagents for not only the understanding of the complex disease processes but also for understanding normal gene functions. In addition, such approach may lead to devising novel diagnostic tools and effective therapies and prevention of human diseases. Currently, the understanding of pathogenesis of diseases, such as diabetes, diabetic neuropathy, retinopathy, hypertension, developmental defects, stroke, and neurodegeneration and regeneration, is the main focus. The Proteomics approach is also being used to further understand the signaling pathways involved in the pathogenesis of above-mentioned diseases.
Contact Person
Dr S.K. Chung
Tel: 2299 0783
Email: skchung@hkucc.hku.hk
Molecular medicine :
Role of nitric oxide in acute and chronic liver and lung injury; hepatic expression of hypoxic inducible factor-1 £\ (HIF-1 £\ ) and its downstream genes in chronic liver hypoxia; signaling pathways of inflammation and oxidative stress in liver and lung injury; role of cyclooxygenase in liver and lung injury.
Contact Person
Dr G.L. Tipoe
Tel: 2819 9185
Email: tgeorge@hkucc.hku.hk
Neuroscience :
Investigation of molecular signaling pathways leading to neuronal death and apoptosis in neurodegenerative disorders (including Alzheimer's disease and glaucoma); neuroprotection and neuroregeneration of the retinal ganglion cells in adult mammals; gene regulation of retinal cell fate determination; morphology and functions of vertebrate nervous system during normal development; search for cure for paralysis associated with spinal cord injury and other CNS diseases; mechanisms of how neurotrophic factors and cell adhesion molecules influence neuronal survival and axonal outgrowth during development and after injury of the nervous system; molecular and cellular interactions between neurons and glial cells.
Contact Persons
Dr W.T. Wu
Tel: 2819 9187
Email: wtwu@hkucc.hku.hk
Dr H. Yip
Tel: 2819 9294
Email: hkfyip@hku.hk
Proteomic research in cancer:
Research on cancer molecular biology, proteomic analyses of carcinogenesis, proteomic research in drug development and biomarker discovery. Ongoing projects: (1) Regulation of a -fetoprotein gene expression in differentiating and cancer cells; (2) Biochemical and proteomic analyses of arsenic carcinogenesis; (3) The Identification of proteomic tumor marker and target proteins of tumors and other human diseases; (4) Proteomic characterization of the cytotoxic mechanism of gold (III) Porphyrin 1a, a potential anticancer drug; (5) Potential of using transcription factor decoys (ODNs) in treatment of patients with lung fibrosis and liver cirrhosis; (6) Proteomic studies on action mechanisms of traditional Chinese medicine; (7) Proteomic determination of action mechanisms of nanosilver as a therapeutic agent.
Contact Person
Professor J.F. Chiu
Tel: 2299 0777
Email: jfchiu@hkucc.hku.hk
Reproduction:
Effects of male accessory sex gland secretion on early embryonic development in golden hamsters (particularly cascade of events in oocyte activation and signal transduction during fertilization); molecular mechanisms involved in ovarian failure in galactosemic rat; role of leptin in pregnancy; oxidative stress in sperm; adrenomedullin and testicular function.
Contact Person
Dr W.S. O
Tel: 2819 9238
Email: owaisum@hkucc.hku.hk
Traditional Chinese medicine:
Effect of various types of TCM on neuroprotection and neuroregeneration of CNS neurons (including eye and spinal cord neurons); mechanisms of antioxidant properties of green tea polyphenols on protection of the liver from carbon tetrachloride toxicity; studies of Chinese herbs that promote blood flow and/or enhance immune response in the treatment of glaucoma and spinal cord trauma.
Contact Person
Professor K.F. So
Tel: 2819 9216
Email: hrmaskf@hkucc.hku.hk
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