Major Research Areas

Histopathology & molecular oncology:
Forensic pathology; patterns of injury in homicides in Hong Kong; patterns of injury and their prevention in traffic fatalities; craniofacial measurements and their use in human identification and recognition; medico-social aspects of victim care; injury patterns in homicides.

Contact Person
Dr P.S.L. Beh
Tel: 2855 4863
Fax: 2872 5197
Email: philipbeh@pathology.hku.hk

Laboratory based studies of tumours of the urogenital system and thyroid.

Contact Person
Dr K.W. Chan
Tel: 2855 4874
Fax: 2872 5197
Email: kwchan@pathology.hku.hk

Molecular Genetics of Colorectal Cancer.

Contact Person
Dr C.T.L. Chan
Tel: 2855 5829
Fax: 2872 5197
Email: tlchan@pathology.hku.hk

Genetics and epigenetics in breast and gynaecological cancers; functional studies of risk associated genes in breast cancer.

Contact Person
Dr K.Y.K. Chan
Tel: 2855 4871
Fax: 2872 5197
Email: kelvinc@pathology.hku.hk

Molecular genetics in diseases of the female genital tract including gynaecological cancers and gestational trophoblastic disease. Genetic susceptibility and signaling pathways of carcinogenesis and metastasis-related genes are some of the research topics.

Contact Person
Professor A.N.Y. Cheung
Tel: 2855 4876
Fax: 2872 5197
Email: anycheun@pathology.hku.hk

Identification of molecular signaling pathway important for cancer metastasis; functional characterization of oncogenes and tumor suppressor genes involved in liver cancer.

Contact Person
Dr W.Y.P. Ching
Tel: 2819 9656
Fax: 2872 5197
Email: ypching@pathology.hku.hk

Genetic and epidemiological study of breast cancer; genetic susceptibility to SARS coronavirus; cancer genetics and epigenetics in breast and gynaecological cancers; studies on Breast Cancer Susceptibility genes BRCA-1 and BRCA-2 in breast and ovarian cancer.

Contact Person
Dr U.S. Khoo
Tel: 2855 4410
Fax: 2872 5197
Email: uskhoo@pathology.hku.hk

Molecular genetic and functional analyses of novel genes and important cellular pathways in liver cancer.

Contact Person
Professor I.O.L. Ng
Tel: 2855 4875
Fax: 2872 5197
Email: iolng@hku.hk

Pathogenetic roles of viruses in NPC and other infectious diseases of the respiratory tract.

Contact Person
Dr J.M. Nicholls
Tel: 2855 4883
Fax: 2872 5197
Email: nicholls@pathology.hku.hk

Molecular genetics in malignancies of the colon and stomach.

Contact Person
Professor S.Y. Leung
Tel: 2855 4401
Fax: 2872 5197
Email: syleung@pathology.hku.hk

Molecular mechanisms and significance of the aberrant nuclear BCL10 expression and constitutive NF-kB activation in NK neoplasms; identification of tumor suppressor genes in the commonly deleted region of 6q in NK neoplasms by employing array-CGH and epigenetic approach; role of the novel immunoglobulin translocation partner genes in the pathogenesis of gastric lymphoma.

Contact Person
Professor G Srivastava
Tel: 2855 3967
Fax: 2872 5197
Email: gopesh@pathology.hku.hk

Molecular genetics and clinicopathological studies of lung cancers including analyses of genomic imbalances, expression profiles, cancer gene mutations and their relation with patients' clinical parameters such as smoking history.

Contact Person
Dr M.P. Wong
Tel: 2855 4861
Fax: 2872 5197
Email: mwpik@hkucc.hku.hk

Molecular biology of important regulators in liver cancer.

Contact Person
Dr J.W.P. Yam
Tel: 2819 9656
Fax: 2872 5197
Email: judyyam@pathology.hku.hk

Haematology:
Major research area is understanding cellular and molecular pathways mediating haemopoieitic stem cell renewal, proliferation and differentiation. Experimental approaches include cloning of chromosomal breakpoints of haemopoieitic malignancies, cellular localisation studies, microarray analysis, gene targetting of embryonic stem cells and mouse models of human leukaemias.

Contact Person
Professor L.C. Chan
Tel: 2855 4882
Fax: 2872 5197
Email: chanlc@pathology.hku.hk

Phenotypic and genotypic studies of thalassaemias, haemoglobinopathies and lymphoid disorders.

Contact Person
Dr J.C.C. So
Tel: 2855 4570
Fax: 2817 7565
Email: scc@pathology.hku.hk

Immunology:
Dendritic cells & immune regulation in immunity & autoimmunity. We study the mechanisms of immune regulation in health and in disease, with a particular emphasis on the roles of dendritic cells (DC) in immunity and autoimmunity. Our current research topics include:

1. DC & immune regulation in systemic lupus erythematosus;
2. Functional conditioning of dendritic cells for DC-based tumor vaccine;
3. DC & T regulatory cells;
4. DC & cell death;
5. DC heterogeneity & functional diversity.

Contact Person
Dr F.P. Huang
Tel: 2855 4864
Fax: 2872 5197
Email: fphuang@hkucc.hku.hk

Lymphocyte development and its dysregulation in autoimmune disease.

We are interested in studying lymphocyte development and its dysregulation during the pathogenesis of autoimmune disease. Using an animal model for human rheumatoid arthritis, we are developing novel strategies for targeting TNF family cytokines in treating autoimmune arthritis.

Contact Person
Dr L.W. Lu
Tel: 2855 4870
Fax: 2872 5197
Email: liweilu@hkucc.hku.hk